Gonadorelin is a synthetic decapeptide structurally identical to endogenous gonadotropin-releasing hormone (GnRH). It consists of ten amino-acid residues with an N-terminal pyroglutamyl residue and an amidated C-terminus. This compact peptide structure functions as the endogenous ligand framework for the GnRH receptor and serves as a reference molecule for studying GnRH receptor signaling and modified GnRH analogs.
C₅₅H₇₅N₁₇O₁₃ This is the molecular formula for gonadorelin base.
Molecular Weight
Approximately 1182.3 g/mol — Gonadorelin base
CAS Number
33515-09-2 — Gonadorelin The FDA substance database identifies this as the primary CAS for gonadorelin.
Amino Acid Sequence
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂
One-letter-style representation:
pE-H-W-S-Y-G-L-R-P-G-NH₂
This is the native mammalian GnRH decapeptide sequence; FDA documentation notes that gonadorelin has the same amino-acid sequence as the natural hormone.
Primary Molecular Target
Gonadotropin-Releasing Hormone Receptor (GnRHR / GnRH1R) GnRHR is the principal receptor through which GnRH regulates anterior pituitary gonadotroph signaling and gonadotropin secretion.
Experimental Applications
GnRH receptor signaling studies
GnRH receptor-binding research
Pituitary gonadotroph studies
LH secretion research
FSH secretion research
Hypothalamic-pituitary-gonadal axis research
Pulsatile GnRH signaling models
GnRH receptor desensitization studies
GnRH agonist/antagonist comparison
Reproductive endocrine signaling
Peptide structure-function analysis
Experimental Systems
Relevant published experimental systems include:
GnRH receptor-expressing cell systems
Isolated pituitary-cell models
Anterior pituitary gonadotroph models
Receptor-transfected cell systems
GnRH receptor-binding models
Gonadotropin secretion systems
Reproductive endocrine models
Human ovarian tissue research systems
Comparative GnRH agonist/antagonist models
GnRH receptor-binding studies have been performed in isolated pituitary cells and receptor-expression systems.
For the actual OPTMZ sample, the directly measured analytical endpoints were identity, purity, net content, appearance, and endotoxin assay performance.
Mechanism / Research Context
Gonadorelin is the synthetic form of endogenous GnRH and functions as an agonist of the gonadotropin-releasing hormone receptor.
GnRH receptor activation on anterior pituitary gonadotroph cells initiates intracellular signaling associated with synthesis and secretion of the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
The biological response to GnRH is strongly influenced by the temporal pattern of receptor stimulation, making Gonadorelin particularly relevant to experimental research involving pulsatile endocrine signaling, receptor desensitization, and hypothalamic-pituitary communication.
Because Gonadorelin reproduces the endogenous GnRH peptide sequence, it should be distinguished from structurally modified, longer-acting GnRH agonists whose substitutions can substantially alter receptor affinity, degradation resistance, and pharmacology. Research comparing GnRH and modified analogs demonstrates that peptide substitutions can materially alter receptor-binding affinity.
Evidence Level
Established Clinical Research Gonadorelin has extensive experimental and human clinical research history, and the molecule has also been used in regulated pharmaceutical products. This classification describes the evidence base surrounding the molecule and does not mean the OPTMZ research product is FDA-approved or intended for clinical use.
Research References
FDA Global Substance Registration System (GSRS): Gonadorelin. Identifies gonadorelin, CAS 33515-09-2, PubChem CID 638793, and associated molecular information. United States Pharmacopeia. Gonadorelin Acetate. USP-NF monograph describing Gonadorelin Acetate and its molecular composition. Flanagan CA, et al. Research describing high-affinity GnRH tracers and receptor-binding assays for analysis of GnRH receptor function. PMID: 9751490. GnRH receptor binding and biological activity study. Research comparing GnRH analog receptor-binding affinity and biological activity in isolated pituitary cells. PMID: 6286282.
Analytical Characterization
Independent analytical testing of OPTMZ Peptides Gonadorelin Acetate 5 mg, lot GND5, by Freedom Diagnostics reported:
Purity (HPLC-UV): 99.94%
Identity (LC-MS): Gonadorelin confirmed
Measured Net Content: 5.84 mg
Label Claim: 5 mg
Appearance: White lyophilized powder
Endotoxin Replicate 1: PASS
Endotoxin Replicate 2: PASS
Assay Sensitivity: ≤0.05 EU/mL
Endotoxin Method: Limulus Amebocyte Lysate assay in accordance with USP <85>
Analytical Method: HPLC with UV detection coupled with LC-MS
Lot: GND5
Accession #: 2606080472
Received: June 8, 2026
Reported: June 9, 2026
These values come directly from the Freedom Diagnostics Certificate of Analysis for the submitted sample.
Gonadorelin Molecular Weight: approximately 1182.3 g/mol
Purity: 99.94%
Identity: Gonadorelin confirmed by LC-MS
Measured Net Content: 5.84 mg
Appearance: White lyophilized powder
Analysis: HPLC-UV coupled with LC-MS
Endotoxin Replicate 1: Pass
Endotoxin Replicate 2: Pass
Endotoxin Assay Sensitivity: ≤0.05 EU/mL
Endotoxin Method: USP <85> LAL assay
Lot: GND5
The lot-specific identity, purity, net content, appearance, and endotoxin results come directly from the Freedom Diagnostics COA.
The FDA’s substance database identifies gonadorelin as CAS 33515-09-2 and PubChem CID 638793.
Important acetate distinction: The COA product is labeled Gonadorelin Acetate, but its analytical identity result is simply Gonadorelin and the COA does not specify acetate stoichiometry. USP describes gonadorelin acetate as C₅₅H₇₅N₁₇O₁₃·xC₂H₄O₂·yH₂O, meaning acetate and hydration can vary. For that reason, I would use the well-defined gonadorelin base formula and molecular weight in the structural fields and identify the marketed material separately as Gonadorelin Acetate rather than assigning an unsupported fixed acetate stoichiometry.
Analytical & Testing
Each tested batch of Gonadorelin Acetate undergoes analytical evaluation to verify peptide identity, chromatographic purity, content, and analytical consistency.
For the submitted OPTMZ Peptides sample, Freedom Diagnostics reported:
Identity (LC-MS): Gonadorelin — Confirmed
Purity (HPLC-UV): 99.94%
Measured Net Content: 5.84 mg
Label Claim: 5 mg
Appearance: White lyophilized powder
Endotoxin Replicate 1: Pass
Endotoxin Replicate 2: Pass
Assay Sensitivity: ≤0.05 EU/mL
Lot: GND5
Accession #: 2606080472
The laboratory states that endotoxin testing was performed using the Limulus Amebocyte Lysate assay in accordance with USP <85>, while peptide characterization used HPLC with UV detection coupled with mass spectrometry.
The single-page COA also displays the chromatogram and mass-confirmation spectrum beneath the analytical-results table.
Handling & Storage
Gonadorelin Acetate should be handled by qualified professionals in controlled laboratory environments. Appropriate storage conditions should be maintained to preserve peptide stability and structural integrity.
Avoid unnecessary exposure to heat, moisture, light, and repeated temperature fluctuations. Experimental preparation, storage, and handling should follow validated laboratory procedures appropriate to the intended research application.
Research Context
Gonadorelin is investigated primarily in endocrine and reproductive-biology research involving the hypothalamic-pituitary-gonadal axis.
Research areas include:
GnRH receptor signaling
Hypothalamic-pituitary signaling
Pituitary gonadotroph biology
Luteinizing hormone signaling
Follicle-stimulating hormone signaling
Gonadotropin secretion
Reproductive endocrinology
GnRH receptor binding
Receptor desensitization/internalization
Pulsatile endocrine signaling
GnRH structure-function research
The peptide’s sequence is equivalent to endogenous mammalian GnRH, making it particularly useful for studying physiological GnRH-receptor signaling rather than the modified pharmacology of longer-acting GnRH analogs. FDA material describes gonadorelin as the generic name for naturally occurring and synthetic GnRH and identifies it as a decapeptide whose sequence is identical to the natural hormone.
GnRH receptor research has included receptor-binding assays and studies examining how peptide modifications alter receptor affinity and biological activity.
Research Application Scope
Gonadorelin is relevant to controlled experimental investigations involving GnRH receptor activation, gonadotropin release, pituitary signaling, reproductive endocrinology, receptor-binding kinetics, and hypothalamic-pituitary communication.
Its status as a synthetic version of native GnRH also makes it useful as a reference ligand in comparative studies involving modified GnRH agonists and antagonists.
Use Statement
For laboratory research use only. Intended strictly for in vitro and controlled experimental research applications.
Disclaimer
All products currently listed on this site are for research purposes ONLY.
Pcs
Single Vial, Pack Of 10
Size
5mg
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