CJC-1295 (without DAC)

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Batch Number: 145030

Purity Percentage: 99.31

Identity Confirmation: CJC-1295 Confirmed

Testing Methods: HPLC-UV/MS

Credential Line: 200510

Test Date: 03/02/2026`

SKU: N/A Category:

Research Data

Research Classification

Short-Acting GHRH Analog / Modified GRF Research Peptide1

Molecular Structure

Molecular Structure

Structure Description

CJC-1295 without DAC is a 29-amino-acid modified GHRH-derived peptide lacking the Drug Affinity Complex present in long-acting CJC-1295. Its structure incorporates substitutions intended to improve stability relative to native GHRH while preserving activity at the growth hormone-releasing hormone receptor.

Research Discipline

Endocrinology; Peptide Biology; GHRH/GH Axis Research; Pituitary Biology; Molecular Signaling; Peptide Pharmacology

Molecular Formula

C₁₅₂H₂₅₂N₄₄O₄₂ PubChem reports this molecular formula for CJC-1295 without DAC.

Molecular Weight

Approximately 3367.9 g/mol This molecular weight is consistent with commercial structural records for CJC-1295 without DAC / Modified GRF (1-29).

CAS Number

863288-34-0 — COA-reported This is the CAS number reported by Krause Analytical for the actual tested CJC-1295 No DAC sample.

Amino Acid Sequence

Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂

One-letter shorthand:

Y-D-A-A-I-F-T-Q-S-Y-R-K-V-L-A-Q-L-S-A-R-K-L-L-Q-D-I-L-S-R-NH₂

A commercial peptide reference lists this sequence for CJC-1295 without DAC.

Primary Molecular Target

Growth Hormone-Releasing Hormone Receptor (GHRHR) Unlike CJC-1295 with DAC, there is no albumin-binding DAC target interaction associated with this form.

Experimental Applications

GHRH receptor signaling studies
Growth hormone secretion pathway research
Pituitary-cell biology
Somatotroph signaling studies
GH/IGF-1 axis research
Peptide stability research
GHRH analog structure-function studies
Comparative DAC versus non-DAC research
Endocrine signaling studies
Modified GRF research

Experimental Systems

Relevant experimental systems include:

GHRH receptor-expressing cell systems
Pituitary cell models
Somatotroph-associated experimental systems
GH secretion assays
Endocrine signaling models
Modified GHRH biochemical systems
Peptide receptor-binding models
Comparative peptide-stability systems

Important: Controlled human CJC-1295 studies primarily concern the DAC-containing form, so those systems should not automatically be represented as evidence for CJC-1295 without DAC.

Specific Assays

HPLC-UV chromatographic purity analysis
LC-MS identity confirmation
Mass-spectrum/reference-spectrum matching
GHRH receptor activation assays
GH secretion assays
Receptor-binding assays
cAMP signaling assays
Pituitary-cell response assays
Peptide stability assays
Comparative pharmacology assays

For the actual OPTMZ product, the COA specifically documents HPLC-UV-MS analysis and mass-spectrum/reference-spectrum matching.

Measured Endpoints

Chromatographic purity
Peptide identity
Peptide content
GHRHR activation
Intracellular cAMP signaling
Growth hormone release
Pituitary-cell response
Peptide stability
Receptor interaction
Endocrine signaling responses

For the actual OPTMZ lot, the directly measured analytical endpoints were purity, identity, and CJC-1295 content.

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Technical Specifications

  • Product: CJC-1295 (without DAC)
  • Quantity: 2 mg label claim
  • Research Classification: Short-Acting GHRH Analog
  • Compound Type: Modified GHRH Peptide Analog
  • Primary Research Target: Growth Hormone-Releasing Hormone Receptor (GHRHR)
  • COA-Reported CAS Number: 863288-34-0
  • Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
  • Molecular Weight: Approximately 3367.9 g/mol
  • Peptide Length: 29 amino acids
  • Chromatographic Purity: 99.31%
  • Identity: CJC-1295 confirmed by HPLC-UV-MS
  • Measured Content: 2.04 mg
  • Percent of Label: 101.9%
  • Analysis Method: HPLC-UV-MS
  • Laboratory: Krause Analytical
  • Lab Number: 200510
  • Project: 145030
  • Report Issued: February 9, 2026

The purity, identity, measured content, and CAS number above come directly from the independent laboratory report for the submitted OPTMZ sample.

PubChem lists CJC-1295 without DAC as C₁₅₂H₂₅₂N₄₄O₄₂.

Analytical & Testing

Each tested batch of CJC-1295 (without DAC) undergoes analytical evaluation to verify chromatographic purity, identity, peptide content, and analytical consistency.

For the submitted OPTMZ Peptides sample, Krause Analytical reported:

  • Chromatographic Purity: 99.31%
  • Identity: CJC-1295 — Confirmed
  • Measured Content: 2.04 mg
  • Label Claim: 2 mg
  • Percent of Label: 101.9%
  • Testing Method: HPLC-UV-MS
  • CAS Number: 863288-34-0
  • Lab Number: 200510
  • Project: 145030

The laboratory states that the data presented are from the analyzed sample and meet its internal quality-assurance criteria unless otherwise flagged.

Page 2 of the report includes both the chromatogram and a direct mass-spectrum/reference-spectrum comparison for the CJC-1295 sample.

Note: This COA does not report endotoxin testing, so I would not state that this specific lot was endotoxin tested.

Handling & Storage

CJC-1295 (without DAC) should be handled by qualified professionals in controlled laboratory environments. Appropriate storage conditions should be maintained to preserve peptide stability and structural integrity.

Avoid unnecessary exposure to heat, moisture, light, and repeated temperature fluctuations. Experimental preparation, storage, and handling should follow validated laboratory procedures appropriate to the intended research application.

Research Context

CJC-1295 (without DAC) is investigated primarily as a GHRH analog for experimental study of the growth hormone-releasing hormone receptor and downstream endocrine signaling.

Research areas include:

  • GHRH receptor signaling
  • Growth hormone secretion pathways
  • IGF-1-associated signaling
  • Pituitary biology
  • Somatotroph signaling
  • Endocrine pathway research
  • GHRH analog structure-function studies
  • Peptide pharmacology
  • Modified GRF research
  • Growth hormone pulse signaling

The non-DAC form is structurally related to Modified GRF (1-29), a stabilized GHRH-derived peptide designed to retain GHRH receptor activity while avoiding the albumin-binding DAC modification.

This distinction is important because much of the published human literature on CJC-1295 specifically concerns the DAC-containing long-acting form, not necessarily the non-DAC peptide. Published CJC-1295 studies therefore should not automatically be used to make pharmacokinetic claims about CJC-1295 without DAC.

Research Application Scope

CJC-1295 (without DAC) is relevant to controlled laboratory investigations involving GHRH receptor biology, pituitary signaling, growth-hormone-associated pathways, endocrine cell signaling, and peptide structure-function relationships.

Because it lacks the Drug Affinity Complex, it is especially relevant to comparative research examining DAC versus non-DAC GHRH analogs and how albumin-binding modifications alter peptide persistence and pharmacology.

Use Statement

For laboratory research use only. Intended strictly for in vitro and controlled experimental research applications.

Disclaimer

All products currently listed on this site are for research purposes ONLY.

Pcs

Single Vial, Pack of 10

Strength

5mg

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