Lot 2026/02 · 10 mg vial · Krause Analytical · reported 13 May 2026 . The bar shows where the reported result falls against Astramide’s published release criterion. The notch marks the criterion.
Within criterionAbove criterionNot on this COA
Test
Method
Criterion
Result
Result vs criterion
Status
Identity
HPLC-UV-MS
Confirmed by mass spectral match
ID Confirmed
WITHIN SPEC
Chromatographic purity
HPLC-UV/MS
at or above 98.0%
99.6 %
95at or above 98.0%100
WITHIN SPEC
Net content
HPLC-UV-MS
8.86 mg
80120
REPORTED
Endotoxin
LAL, USP <85>
below the laboratory's limit of quantitation
<0.5 EU/mL
WITHIN SPEC
Heavy metals, microbial, pH
ICP-MS, USP, potentiometry
not on this report
Not performed
NOT REPORTED
Values are reported per vial or bottle unless otherwise noted. Every figure here is taken from the batch Certificate of Analysis and nothing else.
Krause Analytical · 3 pages · served inline, not a screenshot
Quick reference
How to read this report
Same six keys on every Astramide product page. Only the values change.
1Lot numberMatch it to the number printed on your product label. If they differ, this report is not for your product.
2IdentityMass spectrometry confirms the molecule is the one on the label. It conforms or it does not. There is no partial result.
3Chromatographic purityThe share of the material that is the target peptide. A purity figure quoted without a method is not a purity figure.
4Net contentHow much compound is in each vial or bottle, as measured by the laboratory. A different question from purity.
5EndotoxinMeasured against a ceiling, not a floor. Sensitivity differs by laboratory, so results are not compared across labs.
6Laboratory, method, dateWho ran it, on what instrument, and when. A report with no named laboratory or no date is not a report.
Molecular profile
KPV, in structural terms.
Sequence
Lys-Pro-Val (KPV)
Molecular formula
C₁₆H₃₀N₄O₄
Molecular weight
Approximately 342.44 g/mol
CAS number
67727-97-3
Peptide length
3 amino acids
Structure type
Linear peptide
Parent sequence
alpha-MSH (11-13)
Primary molecular target
Peptide transporter 1 (PepT1, SLC15A1), through which KPV uptake has been demonstrated in intestinal epithelial and immune cell lines. No single high-affinity receptor has been established for KPV.
KPV is a linear tripeptide of L-lysine, L-proline and L-valine. It corresponds to residues 11 to 13 at the C-terminus of alpha-melanocyte-stimulating hormone (alpha-MSH), a 13-amino-acid peptide derived from proopiomelanocortin. KPV is supplied as the free acid (C16H30N4O4), while the parent alpha-MSH sequence ends in a C-terminal amide.
KPV is the C-terminal Lys-Pro-Val tripeptide of alpha-MSH. Reviews of alpha-MSH biology have described KPV as a fragment that has been studied separately from the full hormone because it lacks the parent peptide's pigmentary activity (Brzoska et al., 2008).
In intestinal epithelial and immune cell lines, KPV has been shown to enter cells through the PepT1 di- and tripeptide transporter. Studies have then examined changes in NF-κB and MAP kinase activation and in pro-inflammatory cytokine expression (Dalmasso et al., 2008).
In mouse models, KPV has been examined in two forms of experimentally induced intestinal inflammation. Effects were also observed in mice lacking functional MC1R signaling, which suggests that its activity in these models is not explained by classical melanocortin receptor agonism alone (Kannengiesser et al., 2008).
These are published research systems. They do not describe approved clinical applications, and they do not establish efficacy or safety in humans.
Cited literature
Dalmasso G et al., 2008. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. PMID 18061177. https://pubmed.ncbi.nlm.nih.gov/18061177/
Kannengiesser K et al., 2008. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis. PMID 18092346. https://pubmed.ncbi.nlm.nih.gov/18092346/
Brzoska T et al., 2008. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev. PMID 18612139. https://pubmed.ncbi.nlm.nih.gov/18612139/
Evidence level
The published evidence for KPV consists of cell-line, biochemical and mouse-model studies. Its PepT1 transport has been characterised in vitro. Statements on this page describe experimental systems, not outcomes in humans.
Handling and storage
As supplied
Lyophilized powder in a sealed vial. Held in laboratory-rated freezers from arrival to shipment.
Storage
Store per the conditions printed on the vial label. Avoid heat, moisture and repeated temperature cycling.
Handling
For qualified professionals in controlled laboratory environments, following validated laboratory procedures.
KPV is a linear tripeptide of lysine, proline and valine (Lys-Pro-Val), corresponding to residues 11 to 13 at the C-terminus of alpha-melanocyte-stimulating hormone. Its molecular formula is C16H30N4O4, its molecular weight is about 342.44 g/mol and its CAS number is 67727-97-3. Astramide supplies it as a lyophilized powder in a 10 mg vial. Sold for research use only.
What has KPV been examined for in published research?
Researchers have studied KPV transport in intestinal epithelial models, including uptake via the PepT1 transporter and downstream effects on inflammatory signalling pathways in cell and animal models (Dalmasso et al., 2008, PMID 18061177). Published work is pre-clinical. Astramide makes no claim about outcomes in humans.
What purity does the current KPV lot reach?
Lot 2026/02 returned 99.6% chromatographic purity by HPLC-UV/MS, tested by Krause Analytical under Lab No. 205091 and reported 13 May 2026. Identity was confirmed by mass spectral match. The full Certificate of Analysis is published on the lot record and is downloadable as the laboratory’s own PDF.
How much KPV is in the vial?
The label claim is 10 mg. Lot 2026/02 measured 8.86 mg of KPV, which is 88.6% of label. Astramide publishes the measured figure rather than the label figure. Net content is a separate question from purity.
How is Astramide's KPV tested?
Testing is performed by Krause Analytical, a DEA-registered, ISO/IEC 17025-certified laboratory in Austin, Texas. Lot 2026/02 was analysed by four methods: identity by mass spectral match, chromatographic purity by HPLC-UV/MS, net content by HPLC-UV/MS, and endotoxin by USP 85. Heavy metals, microbial and pH were not performed on this lot, and the report says so.
How should KPV be stored for research use?
Lyophilized material is stored at -20C and protected from light. Once reconstituted, storage is 2 to 8C with use within 14 to 30 days. Storage conditions affect peptide stability, and results from this lot apply to material handled within these conditions.
What is the difference between research-grade and pharmaceutical-grade KPV?
These are separate classifications. Research-grade material is supplied for laboratory research use only and is not manufactured, tested or released under the regulatory framework that governs drugs for human use. Pharmaceutical-grade is an FDA classification for human-use products. Astramide supplies research-grade material exclusively and does not represent it as pharmaceutical-grade.
Is KPV the same as the KLOW blend?
No. KLOW is a separate product combining KPV with GHK-Cu, BPC-157 and TB-500. It carries its own lot number and its own Certificate of Analysis. A COA for one product never applies to another, and a blend is tested as a blend.
Research use only
This product is intended strictly for in-vitro laboratory research conducted by qualified professionals.
It is not intended for human or animal consumption, clinical use, or therapeutic application.
The statements on this page have not been reviewed by the FDA. These research peptides are not intended
to diagnose, treat, cure, or prevent any disease. Research Use Only.
Get It Now
This product has multiple variants. The options may be chosen on the product page
Added to your cart
Your cart is empty.
Your Privacy Choices
We use analytics and advertising tools to understand how visitors find us and which campaigns work. You can turn either off. Your choice is saved in this browser.
AnalyticsGoogle Analytics, Microsoft Clarity and order source tracking. Helps us see how the site is used and fix problems.
Off (browser signal)
AdvertisingMeta and X pixels, and server-side events. Opting out also opts you out of "sharing" and targeted advertising under state privacy laws.
Off (browser signal)
Your browser is sending a Global Privacy Control signal, so analytics and advertising are off. To change this, turn off the signal in your browser settings.
Strictly necessary cookies (cart, sign-in, checkout, entry acknowledgment) always stay on. See our Privacy Policy.
Know what's in it before you order.
Every Astramide batch is tested by an independent US lab. The report goes public before the batch goes on sale, so you can check the numbers first.
Independent US lab test on every batch
Full report published before it goes on sale
Kept frozen, shipped from Austin, Texas
GLP-3RLot 2026/02 · May 8, 2026
>99.9%purity by HPLC-UV/MS
90%Minimum 98.0%100%
Identity: Confirmed by mass specEndotoxin: Below 0.5 EU/mL
Pro Series
