Research Use Only

All research peptides supplied by OPTMZ Peptides are intended strictly for laboratory research applications and are not designed for medical use. These materials are not approved by the U.S. Food and Drug Administration (FDA) to diagnose, treat, cure, or prevent any disease. By purchasing, the buyer confirms use strictly for scientific research purposes and not for human or animal consumption.

Product Overview

IGF-1 LR3 (Long R3 Insulin-Like Growth Factor-1) is an 83-amino-acid research analog of human insulin-like growth factor-1 (IGF-1). It differs structurally from native IGF-1 through an arginine substitution at position 3 and the addition of a 13-amino-acid N-terminal extension.

These modifications are investigated for their effects on interactions with insulin-like growth factor binding proteins (IGFBPs), IGF-1 receptor signaling, and downstream cellular pathways. IGF-1 LR3 is widely used as an experimental reagent in controlled studies of growth-factor biology and cellular signaling.

Technical Specifications

Product: IGF-1 LR3 (Long R3 IGF-1)
Quantity: 1 mg
CAS Number: 946870-92-4
Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
Molecular Weight: Approximately 9,111 Da
Peptide Length: 83 amino acids
Purity: >99.9% (HPLC-UV/MS tested for current lot)
Form: Peptide research material
Identity: Confirmed by mass spectral analysis
Synonyms: Long R3 IGF-1, Long R3 IGF-I, LR3-IGF-1, Long Arg3 IGF-1

The CAS number is specifically reported on your independent laboratory COA. The 83-amino-acid length, approximately 9,111-Da molecular mass, Arg3 substitution, and 13-amino-acid extension are also described in technical literature for Long R3 IGF-I.

Analytical & Testing

Each batch of IGF-1 LR3 undergoes analytical testing to verify purity, identity, and analytical consistency. A corresponding Certificate of Analysis (COA) is available for each tested batch.

For the current OPTMZ Peptides lot, independent testing by Krause Analytical reported:

Chromatographic Purity: >99.9%
Testing Method: HPLC-UV/MS
Mass Spectral Match: Identity confirmed
Measured Content: 1.10 mg
Label Claim: 1 mg
Percent of Label: 110%
Endotoxins: <0.5 EU/mL
Endotoxin Method: USP <85>
Batch/Lot: 2026/02

These values are reported on a per-vial basis according to the laboratory report.

The COA also includes the underlying chromatogram on page 2 and mass-spectral report on page 3, providing additional analytical documentation for the tested sample.

Handling & Storage

IGF-1 LR3 should be handled by qualified professionals in controlled laboratory environments. Appropriate storage conditions should be maintained to preserve compound stability and structural integrity.

Avoid unnecessary exposure to heat, moisture, and repeated temperature fluctuations. Handling and preparation procedures should follow the requirements of the applicable experimental protocol.

Research Context

In laboratory and preclinical research systems, IGF-1 LR3 has been investigated across growth-factor, receptor-signaling, biochemical, and cellular models. Research areas include:

IGF-1 receptor (IGF-1R) signaling
IGF-binding protein interactions
Growth-factor biology
Cellular proliferation pathways
Cellular differentiation models
Protein synthesis signaling
PI3K/Akt pathway research
MAPK signaling
Metabolic signaling
Cell-culture growth models

The structural modifications of Long R3 IGF-I markedly reduce its interaction with IGF-binding proteins compared with native IGF-I, which is one reason the analog is useful as an experimental reagent in systems containing IGFBPs.

These observations relate to controlled experimental systems and do not establish therapeutic efficacy or safety in humans.

Research Application Scope

IGF-1 LR3 continues to be evaluated in experimental biology, particularly within studies involving growth-factor receptor activation, IGF-binding protein interactions, intracellular signaling, cellular proliferation and differentiation, and biochemical pathway analysis.

Its 83-amino-acid structure and reduced affinity for IGF-binding proteins distinguish IGF-1 LR3 from native 70-amino-acid IGF-1 and make it useful for laboratory investigations of the IGF signaling system.

Use Statement

For laboratory research use only. Intended strictly for in vitro research applications.

Disclaimer

All products currently listed on this site are for research purposes ONLY.

Pcs	Single Vial, Pack Of 10

Reviews

There are no reviews yet.

Be the first to review “IGF-1 LR3”