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Kisspeptin Pro research peptide vial, Astramide Pro Series, 5 mg lot tested at 99% HPLC purity
Kisspeptin Pro research peptide vials, pack of 10, Astramide Pro Series
  1. Kisspeptin Pro research peptide vial, Astramide Pro Series, 5 mg lot tested at 99% HPLC purity
  2. Kisspeptin Pro research peptide vials, pack of 10, Astramide Pro Series

Kisspeptin Pro

Pro Series
Kisspeptin-10, the C-terminal decapeptide of kisspeptin and a KISS1R (GPR54) agonist
CAS 374675-21-5C₆₃H₈₃N₁₇O₁₄Approximately 1302.4 g/mol10 amino acidsLinear peptideLyophilized powder

Price range: $50.00 through $650.00

Ships from lot NHS-KIS05-20260918-01 · 5 mg vial · 99% purity · pH Solutions Lab See the COA
Why the Pro Series costs more
  • Synthesized in the USA. Domestic ground and air only, no ocean freight.
  • Released only above 99% HPLC purity.
  • Its own lot and its own published certificate.
How the Pro Series is made and tested
Ships from Austin, TexasUnited States only
Tested by an outside labNever in-house
Every lot publishedIncluding rejected lots
Same-day dispatchOn orders before 2pm ET
SKU: N/A Category: Tags: ,
BATCH
VERIFICATION
LOT NUMBER
NHS-KIS05-20260918-01
5 mg vial
IDENTITY
Match (C63H83N17O14, 1302.4 g/mol, CAS 374675-21-5)
CHROMATOGRAPHIC PURITY
99%
NET CONTENT
5.0649 mg (101.298% of 5 mg label claim)
Analytical characterization

Every result against its specification.

Lot NHS-KIS05-20260918-01 · 5 mg vial · pH Solutions Lab · reported 29 September 2026 . The bar shows where the reported result falls against Astramide’s published release criterion. The notch marks the criterion.
Within criterion Above criterion Not on this COA
Test
Method
Criterion
Result
Result vs criterion
Status
Identity
Match to the labelled compound
Match (C63H83N17O14, 1302.4 g/mol, CAS 374675-21-5)
WITHIN SPEC
Chromatographic purity
HPLC (274 nm)
at or above 99.0%
99%
95 at or above 99.0% 100
WITHIN SPEC
Net content
5.0649 mg (101.298% of 5 mg label claim)
80 120
REPORTED
Appearance
Visual
white lyophilized powder
White to off-white lyophilized powder cake, free of visible particulates
WITHIN SPEC
Water content
Karl Fischer
reported
0.0%
WITHIN SPEC
pH
reported
7.0
WITHIN SPEC
Water activity
within laboratory limit
0.2542 aw, pass
WITHIN SPEC
Microbial panel
not detected
Pass, 10 organisms and counts not detected
WITHIN SPEC
Heavy metals
within laboratory limits
Pass. As, Cd, Hg 0.000 ppm; Pb 0.042 ppm
WITHIN SPEC
Residual solvents
within laboratory limits
Pass, 12 solvents; acetonitrile 0.067, butane 0.032, methanol 0.004 ppm; others 0.000 ppm
WITHIN SPEC
Sterility
sterile
Pass
WITHIN SPEC
Mycotoxins
within laboratory limits
Pass
WITHIN SPEC
Endotoxin
LAL
—
Not reported on this certificate
NOT REPORTED
Values are reported per vial unless otherwise noted. Every figure here is taken from the batch Certificate of Analysis and nothing else.
Certificate of Analysis
Kisspeptin Pro · Lot NHS-KIS05-20260918-01 · 5 mg vial · Lab No. NHS-KIS05-20260918-01
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Quick reference

How to read this report

Same six keys on every Astramide product page. Only the values change.
1Lot numberMatch it to the number printed on your vial. If they differ, this report is not for your vial.
2IdentityMass spectrometry confirms the molecule is the one on the label. It conforms or it does not. There is no partial result.
3Chromatographic purityThe share of the material that is the target peptide. A purity figure quoted without a method is not a purity figure.
4Net contentHow much peptide is in the vial, as measured by the laboratory. A different question from purity.
5EndotoxinMeasured against a ceiling, not a floor. Sensitivity differs by laboratory, so results are not compared across labs.
6Laboratory, method, dateWho ran it, on what instrument, and when. A report with no named laboratory or no date is not a report.
Molecular profile

Kisspeptin Pro, in structural terms.

Kisspeptin Pro molecular structure
Sequence
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ (YNWNSFGLRF-NH₂)
Molecular formula
C₆₃H₈₃N₁₇O₁₄
Molecular weight
Approximately 1302.4 g/mol
CAS number
374675-21-5
Peptide length
10 amino acids
Structure type
Linear peptide
Parent sequence
Kisspeptin-54 (metastin), residues 45-54; a product of the KISS1 gene
Primary molecular target
KISS1 receptor (KISS1R), formerly the orphan G protein-coupled receptor GPR54. Kisspeptins bound human and rat GPR54 with low nanomolar affinity and signalled through PIP2 hydrolysis and calcium mobilization in cell-based studies (Kotani et al., 2001).
Physical form
Lyophilized powder
PubChem CID
25240297

Kisspeptin-10 is a linear ten-amino-acid peptide, Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂, with a C-terminal phenylalaninamide. It is the C-terminal fragment of kisspeptin-54, also called metastin, and carries the Arg-Phe-amide (RF-amide) C terminus shared by all kisspeptins. Its formula is C₆₃H₈₃N₁₇O₁₄ and its molecular weight is about 1302.4 g/mol.

Research profile

Where Kisspeptin Pro appears in the literature.

Neuroendocrinology; Reproductive Endocrinology; Receptor Pharmacology; GPCR Signaling; Peptide Chemistry
Research applications
  • Published studies have used kisspeptins in:
  • KISS1R (GPR54) binding and signalling studies
  • GnRH release studies in hypothalamic models
  • GPCR second-messenger and MAP kinase assays
  • Structure-activity studies of RF-amide peptides
Experimental systems
  • CHO-K1 cells expressing rat or human GPR54
  • Mouse models, including GPR54 knockout mice
  • Sheep models with cerebrospinal fluid sampling
  • Human placental tissue extracts used for peptide isolation
Specific assays
  • Receptor binding assays
  • Calcium mobilization and PIP2 hydrolysis assays
  • ERK1/2 and p38 MAP kinase phosphorylation
  • In situ hybridization of GPR54 transcripts
  • GnRH, LH and FSH immunoassays
  • HPLC and mass spectrometry for purity and identity
Measured endpoints
  • Receptor binding affinity
  • Intracellular calcium and inositol phosphate signalling
  • MAP kinase phosphorylation
  • GnRH release into cerebrospinal fluid
  • Serum LH and FSH in animal models
Pcs

Single Vial, Pack of 10
Strength

5mg, 10mg
Mechanism and research context

What has been studied, and in what systems.

In 2001, two groups independently identified the products of the KiSS-1 gene as the natural ligands of the orphan receptor GPR54. One group isolated metastin, a 54-amino-acid peptide amide (Ohtaki et al., 2001). The other isolated 54-, 14- and 13-amino-acid peptides from human placenta, named them kisspeptins, and showed that they share an RF-amide C terminus and bind rat and human GPR54 with low nanomolar affinity (Kotani et al., 2001). Kisspeptin-10 is the shortest C-terminal fragment of this family.

Later work in mice found GPR54 transcripts colocalized with GnRH neurons in the hypothalamus. Kisspeptin raised LH and FSH in wild-type mice but had no effect in mice lacking GPR54, and in sheep, central administration released GnRH into the cerebrospinal fluid (Messager et al., 2005). These studies place kisspeptin in reproductive neuroendocrinology and GPCR research.

These are published research systems. They do not describe approved clinical applications, and they do not establish efficacy or safety in humans.

Cited literature

Ohtaki T, Shintani Y, Honda S, Matsumoto H, et al., 2001. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature. PMID 11385580. https://pubmed.ncbi.nlm.nih.gov/11385580/
Kotani M, Detheux M, Vandenbogaerde A, Communi D, et al., 2001. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem. PMID 11457843. https://pubmed.ncbi.nlm.nih.gov/11457843/
Messager S, Chatzidaki EE, Ma D, Hendrick AG, et al., 2005. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci U S A. PMID 15665093. https://pubmed.ncbi.nlm.nih.gov/15665093/

Evidence level
Kisspeptin receptor identity and signalling are established in cell-based studies, and its action on GnRH neurons is characterized in mouse and sheep models. Statements on this page describe experimental systems, not outcomes in humans.
Handling and storage
As supplied
Lyophilized powder in a sealed vial. Held in laboratory-rated freezers from arrival to shipment.
Storage
Store per the conditions printed on the vial label. Avoid heat, moisture and repeated temperature cycling.
Handling
For qualified professionals in controlled laboratory environments, following validated laboratory procedures.
Frequently asked questions

About this compound and its batch data.

What is kisspeptin-10?

Kisspeptin-10 is a linear ten-amino-acid peptide, Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2, the C-terminal fragment of kisspeptin-54. Its formula is C63H83N17O14, its molecular weight is about 1302.4 g/mol and its CAS number is 374675-21-5 (PubChem CID 25240297). Kisspeptin Pro is supplied as a lyophilized powder. Sold for research use only.

What receptor does kisspeptin act on?

Kisspeptins are the natural ligands of KISS1R, a G protein-coupled receptor formerly known as the orphan receptor GPR54. In cell-based studies, kisspeptins bound rat and human GPR54 with low nanomolar affinity and triggered PIP2 hydrolysis, calcium mobilization and MAP kinase phosphorylation (Kotani et al., 2001, PMID 11457843).

What has kisspeptin been examined for in published research?

Kisspeptins were identified in 2001 as the GPR54 ligands (Ohtaki et al., PMID 11385580; Kotani et al., PMID 11457843). In mice, kisspeptin raised LH and FSH in wild-type animals but not in GPR54 knockouts, and in sheep it released GnRH into cerebrospinal fluid (Messager et al., 2005, PMID 15665093). Astramide makes no claim about outcomes in humans.

What purity does the current Kisspeptin Pro lot reach?

Lot NHS-KIS05-20260918-01 returned 99% chromatographic purity by HPLC at 274 nm, reported by pH Solutions Lab on 29 September 2026 under certificate 260922-NHS-5. Identity was confirmed as a match to kisspeptin-10 (C63H83N17O14, 1302.4 g/mol). The lot meets the Pro Series release criterion of at or above 99% HPLC purity. The full certificate is published on this page.

How much kisspeptin is in the vial?

The label claim for this lot is 5 mg per vial. For lot NHS-KIS05-20260918-01, the laboratory measured 5.0649 mg of kisspeptin-10, which is 101.298% of the label claim. Astramide publishes the measured figure exactly as the laboratory reports it, above or below the label. Net content and chromatographic purity are separate measurements.

How should kisspeptin be stored for research use?

Lyophilized kisspeptin-10 is stored at -20°C and protected from light. Once reconstituted, the solution is held at 2 to 8°C and used within 14 to 30 days. Repeated temperature cycling and exposure to moisture should be avoided, because both can affect peptide stability and the comparability of experimental results.

How is Astramide's Kisspeptin Pro tested?

Lot NHS-KIS05-20260918-01 was tested by pH Solutions Lab, an independent ISO/IEC 17025:2017 accredited laboratory (A2LA R243, PJLA Testing #84351). The certificate reports identity, purity at 274 nm, net content, water content, pH, water activity, a 10-organism microbial panel, heavy metals, residual solvents, sterility and mycotoxins. Endotoxin is not reported. Results apply only to this lot.

What does Pro Series mean for Kisspeptin Pro?

Kisspeptin Pro is part of the Astramide Pro Series. It is American-made, synthesized in the USA, and moves by domestic ground and air only, with no ocean freight. It is released under its own lot, and only when HPLC purity measures at or above 99%. The full certificate for each lot is published on this page.

Research use only

This product is intended strictly for in-vitro laboratory research conducted by qualified professionals. It is not intended for human or animal consumption, clinical use, or therapeutic application. The statements on this page have not been reviewed by the FDA. These research peptides are not intended to diagnose, treat, cure, or prevent any disease. Research Use Only.

COA library Every lot we have tested Search by batch number. Past lots stay published. How we test The analytical panel What each method measures and the criterion each lot must meet. Open Lab Send us your peptides Any vendor. Same lab. Your own Certificate of Analysis.
Ships from Austin, TexasUSPS or UPS, your choice
United States onlyFree shipping at $150 and over
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Replacement or store creditOn approved claims. See refund policy.

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