SNAP-8, a synthetic eight-amino-acid peptide supplied as a lyophilized powder
CAS 868844-74-0C₄₁H₇₀N₁₆O₁₆SPubChem CID 76283482.1075.2 g/molNet peptide content is reported on a per-vial basis on the certificate of analysis published on this page.8 amino acidsLinear peptideLyophilized powder
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Lot NP810 · 10 mg vial · Freedom Diagnostics · reported 9 June 2026 . The bar shows where the reported result falls against Astramide’s published release criterion. The notch marks the criterion.
Within criterionAbove criterionNot on this COA
Test
Method
Criterion
Result
Result vs criterion
Status
Identity
LC-MS
LC-MS match to the labelled compound
Confirmed
WITHIN SPEC
Chromatographic purity
HPLC-UV
at or above 98.0%
99.18%
95at or above 98.0%100
WITHIN SPEC
Net content
HPLC-UV
11.54 mg
80120
REPORTED
Endotoxin
LAL, USP <85>
below the 0.05 EU/mL assay sensitivity
Pass, 2 of 2 at ≤0.05 EU/mL
WITHIN SPEC
Appearance
Visual
white lyophilized powder
White Lyophilized Powder
WITHIN SPEC
Values are reported per vial or bottle unless otherwise noted. Every figure here is taken from the batch Certificate of Analysis and nothing else.
Freedom Diagnostics · 1 page · served inline, not a screenshot
Quick reference
How to read this report
Same six keys on every Astramide product page. Only the values change.
1Lot numberMatch it to the number printed on your product label. If they differ, this report is not for your product.
2IdentityMass spectrometry confirms the molecule is the one on the label. It conforms or it does not. There is no partial result.
3Chromatographic purityThe share of the material that is the target peptide. A purity figure quoted without a method is not a purity figure.
4Net contentHow much compound is in each vial or bottle, as measured by the laboratory. A different question from purity.
5EndotoxinMeasured against a ceiling, not a floor. Sensitivity differs by laboratory, so results are not compared across labs.
6Laboratory, method, dateWho ran it, on what instrument, and when. A report with no named laboratory or no date is not a report.
Molecular profile
Snap-8, in structural terms.
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂
One-letter representation:
Ac-EEMQRRAD-NH₂
The sequence corresponds to residues 12–19 of human SNAP-25 (UniProt P60880). SNAP-8 extends the shorter hexapeptide acetyl hexapeptide-8 by two residues at the C-terminus.
Molecular formula
C₄₁H₇₀N₁₆O₁₆SPubChem CID 76283482.
Molecular weight
1075.2 g/molNet peptide content is reported on a per-vial basis on the certificate of analysis published on this page.
CAS number
868844-74-0 — Acetyl octapeptide-3 (SNAP-8)
Peptide length
8 amino acids
Structure type
Linear peptide
Primary molecular target
SNAP-25 within the SNARE complex (syntaxin-1A, VAMP-2, SNAP-25)The proposed mechanism is competitive interference with SNAP-25 incorporation into the ternary SNARE complex, reducing the efficiency of vesicle docking and fusion. This model derives from in vitro complex assembly work rather than from receptor binding studies.
SNAP-8 is an eight-residue peptide that reproduces a segment of the N-terminal region of SNAP-25, a core component of the SNARE complex that mediates vesicle fusion at the presynaptic membrane. The peptide is N-terminally acetylated and C-terminally amidated. It is studied as a competitive mimic that can occupy a SNAP-25 binding position within the assembling complex.
Research on SNAP-8 sits at the intersection of two literatures: the well-established structural and functional biology of the SNARE complex, and a smaller applied literature concerning peptide delivery in topical formulation. Compound-specific primary research on the octapeptide itself is limited; most mechanistic understanding is inferred from the broader SNARE literature and from work on the related hexapeptide.
These are published research systems. They do not describe approved clinical applications, and they do not establish efficacy or safety in humans.
Cited literature
Palfreyman MT et al., 2023. SNARE Proteins in Synaptic Vesicle Fusion. Adv Neurobiol. PMID 37615864. https://pubmed.ncbi.nlm.nih.gov/37615864/
Rizo J et al., 2024. Molecular mechanism underlying SNARE-mediated membrane fusion enlightened by all-atom molecular dynamics simulations. Proc Natl Acad Sci U S A. PMID 38593076. https://pubmed.ncbi.nlm.nih.gov/38593076/
Yang J et al., 2022. A dynamic template complex mediates Munc18-chaperoned SNARE assembly. Proc Natl Acad Sci U S A. PMID 36454760. https://pubmed.ncbi.nlm.nih.gov/36454760/
Evidence level
The SNARE complex biology underlying this peptide is extensively characterised in published structural and cell biological work, including molecular dynamics of membrane fusion and the chaperoned assembly pathway. Primary research on the octapeptide itself is sparse, and its proposed competitive mechanism is inferred from the broader SNARE literature rather than directly demonstrated for this sequence. Statements on this page describe experimental systems only.
Handling and storage
As supplied
Lyophilized powder in a sealed vial. Held in laboratory-rated freezers from arrival to shipment.
Storage
Store per the conditions printed on the vial label. Avoid heat, moisture and repeated temperature cycling.
Handling
For qualified professionals in controlled laboratory environments, following validated laboratory procedures.
Frequently asked questions
About this compound and its batch data.
What purity did this Snap-8 batch achieve?
Lot NP810 was analysed by Freedom Diagnostics and returned chromatographic purity of 99.18% by HPLC with UV detection coupled to mass spectrometry. Identity was confirmed by mass spectral match. The full certificate is published on this page, and every figure shown here is taken from it.
How much Snap-8 is in the vial?
The laboratory measured 11.54 mg, which is 115.4% of the label claim. Net content is reported on a per-vial basis. Astramide publishes the measured figure rather than the label claim, whether it falls above or below.
Was this Snap-8 batch tested for endotoxins?
Yes. Endotoxin testing was performed using the Limulus Amebocyte Lysate assay in accordance with USP <85>, and this batch returned Pass, 2 of 2 at ≤0.05 EU/mL. The result appears on the certificate published on this page.
How should Snap-8 be stored for research use?
As supplied, the lyophilized powder should be held at -20°C and protected from light and moisture. Once reconstituted, store at 2-8°C and use within 14 to 30 days. Avoid repeated freeze-thaw cycles and follow the handling procedures appropriate to your laboratory.
What is the difference between research-grade and pharmaceutical-grade Snap-8?
These are separate classifications. Research-grade material is supplied for laboratory research use only and is not intended for human or animal consumption. Pharmaceutical-grade is an FDA classification that applies to drugs manufactured for human use. Astramide supplies research-grade material only.
How can I verify this Snap-8 certificate independently?
The certificate was issued by Freedom Diagnostics under lot NP810, laboratory reference 2606080460. Quote that reference to the laboratory directly. The same document is published here in full, and is not summarised or reformatted by Astramide.
Research use only
This product is intended strictly for in-vitro laboratory research conducted by qualified professionals.
It is not intended for human or animal consumption, clinical use, or therapeutic application.
The statements on this page have not been reviewed by the FDA. These research peptides are not intended
to diagnose, treat, cure, or prevent any disease. Research Use Only.
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Know what's in it before you order.
Every Astramide batch is tested by an independent US lab. The report goes public before the batch goes on sale, so you can check the numbers first.
Independent US lab test on every batch
Full report published before it goes on sale
Kept frozen, shipped from Austin, Texas
GLP-3RLot 2026/02 · May 8, 2026
>99.9%purity by HPLC-UV/MS
90%Minimum 98.0%100%
Identity: Confirmed by mass specEndotoxin: Below 0.5 EU/mL
Pro Series
Pro Series