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Glutathione

Glutathione

Glutathione, the endogenous tripeptide gamma-Glu-Cys-Gly
CAS 70-18-8C₁₀H₁₇N₃O₆S307.32 g/molLinear peptideLyophilized powder

Price range: $70.00 through $616.00

Ships from lot 2026/02 · 1500 mg vial · >99.9 % purity · Krause Analytical See the COA

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Also available in the Pro Series.Its own lot. Its own certificate.
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Ships from Austin, TexasUnited States only
Tested by an outside labNever in-house
Every lot publishedIncluding rejected lots
Same-day dispatchOn orders before 2pm ET
SKU: N/A Category:
BATCH
VERIFICATION
LOT NUMBER
2026/02
1500 mg vial
IDENTITY
Confirmed
CHROMATOGRAPHIC PURITY
>99.9 %
NET CONTENT
1,480 mg
Analytical characterization

Every result against its specification.

Lot 2026/02 · 1500 mg vial · Krause Analytical · reported 13 May 2026 . The bar shows where the reported result falls against Astramide’s published release criterion. The notch marks the criterion.
Within criterion Above criterion Not on this COA
Test
Method
Criterion
Result
Result vs criterion
Status
Identity
HPLC-UV-MS
Mass spectral match to the labelled compound
Confirmed
WITHIN SPEC
Chromatographic purity
HPLC-UV/MS
at or above 98.0%
>99.9 %
95 at or above 98.0% 100
WITHIN SPEC
Net content
HPLC-UV-MS
1,480 mg
80 120
REPORTED
Endotoxin
LAL, USP <85>
below the 0.5 EU/mL limit of quantification
<0.5 EU/mL
WITHIN SPEC
Values are reported per vial or bottle unless otherwise noted. Every figure here is taken from the batch Certificate of Analysis and nothing else.
Certificate of Analysis
Glutathione · Lot 2026/02 · 1500 mg vial · Lab No. 205092
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Quick reference

How to read this report

Same six keys on every Astramide product page. Only the values change.
1Lot numberMatch it to the number printed on your product label. If they differ, this report is not for your product.
2IdentityMass spectrometry confirms the molecule is the one on the label. It conforms or it does not. There is no partial result.
3Chromatographic purityThe share of the material that is the target peptide. A purity figure quoted without a method is not a purity figure.
4Net contentHow much compound is in each vial or bottle, as measured by the laboratory. A different question from purity.
5EndotoxinMeasured against a ceiling, not a floor. Sensitivity differs by laboratory, so results are not compared across labs.
6Laboratory, method, dateWho ran it, on what instrument, and when. A report with no named laboratory or no date is not a report.
Molecular profile

Glutathione, in structural terms.

Glutathione molecular structure
Sequence
γ-Glu-Cys-Gly Glutathione is a tripeptide in which the glutamate residue is joined to cysteine through its side-chain γ-carboxyl group rather than the α-carboxyl group used in standard peptide bonds. This isopeptide linkage is the reason glutathione is not a substrate for most conventional peptidases.
Molecular formula
C₁₀H₁₇N₃O₆S
Molecular weight
307.32 g/mol
CAS number
70-18-8
Structure type
Linear peptide
Primary molecular target
Glutathione peroxidase and glutathione reductase enzyme systems; cellular thiol redox couple (GSH/GSSG)
Physical form
Lyophilized powder
PubChem CID
124886

Glutathione is the tripeptide gamma-Glu-Cys-Gly. The formula and molecular weight shown are derived from that sequence, with the gamma-linkage between the glutamate side chain and cysteine. The free thiol on the cysteine residue is the reactive centre in redox chemistry.

Research profile

Where Glutathione appears in the literature.

Redox Biochemistry; Cell Biology; Enzymology; Oxidative Stress Research; Analytical Chemistry
Research applications
  • Cellular redox homeostasis
  • Oxidative-stress models
  • Reactive oxygen species (ROS) research
  • Glutathione redox-cycle studies
  • Glutathione peroxidase pathways
  • Glutathione reductase pathways
  • Thiol and sulfhydryl biology
  • Cellular antioxidant systems
Experimental systems
  • Cultured mammalian cell lines
  • Isolated mitochondrial preparations
  • Enzyme assay systems
  • Cell-free redox buffers
  • Peroxisome preparations
  • Rodent tissue homogenates
Specific assays
  • HPLC purity analysis
  • Thiol quantification assays
  • Glutathione peroxidase activity assays
  • Glutathione reductase activity assays
  • Reduced-to-oxidised glutathione ratio determination
  • Reactive oxygen species scavenging assays
  • Spectrophotometric enzyme kinetics
Measured endpoints
  • Chromatographic purity
  • Compound identity
  • Reduced glutathione concentration
  • GSH to GSSG ratio
  • Enzyme activity rate
  • Reactive oxygen species scavenging capacity
  • Cellular redox potential
Pcs

Single Vial, 3-Pack, 6-Pack, Pack of 10
Strength

1500mg
Mechanism and research context

What has been studied, and in what systems.

Glutathione is extensively investigated in biochemical and cellular research because of its central role in intracellular redox systems.

These are published research systems. They do not describe approved clinical applications, and they do not establish efficacy or safety in humans.

Cited literature

Brigelius-Flohé R et al., 2013. Glutathione peroxidases. Biochim Biophys Acta. PMID 23201771. https://pubmed.ncbi.nlm.nih.gov/23201771/

Ferreira JV et al., 2023. Glutathione and peroxisome redox homeostasis. Redox Biol. PMID 37804696. https://pubmed.ncbi.nlm.nih.gov/37804696/

Evidence level
Extensive published literature. Glutathione is an endogenous tripeptide and one of the most widely studied molecules in redox biochemistry, appearing across biochemical, cellular and animal-model research. This describes the evidence base surrounding the molecule and does not imply approval or established efficacy for the research material supplied here.
Handling and storage
As supplied
Lyophilized powder in a sealed vial. Held in laboratory-rated freezers from arrival to shipment.
Storage
Store per the conditions printed on the vial label. Avoid heat, moisture and repeated temperature cycling.
Handling
For qualified professionals in controlled laboratory environments, following validated laboratory procedures.
Frequently asked questions

About this compound and its batch data.

What is glutathione?

Glutathione is a tripeptide of glutamate, cysteine and glycine, CAS 70-18-8, C10H17N3O6S, 307.32 g/mol. It is the most abundant low-molecular-weight thiol in mammalian cells. Astramide supplies it as a lyophilized powder for laboratory research use only. It is not intended for human or animal consumption, clinical use, or therapeutic application.

What has glutathione been examined for in published research?

Glutathione is one of the most extensively characterised molecules in redox biochemistry. Published work covers its role as a cofactor for glutathione peroxidases and transferases, the GSH to GSSG ratio as a measure of cellular redox state, and conjugation chemistry in xenobiotic metabolism. Astramide makes no claim about outcomes in humans.

What purity does the current glutathione lot reach?

Lot 2026/02 returned greater than 99.9% chromatographic purity by HPLC-UV/MS, tested by Krause Analytical under Lab No. 205092 and reported 13 May 2026. Identity was confirmed by mass spectral match to the labelled compound. The full certificate is published on this page and every figure shown here is taken from it.

How much glutathione is in the vial?

The label claim is 1,500 mg. Lot 2026/02 measured 1,480 mg of glutathione, which is 98.5% of label. Astramide publishes the measured figure rather than the label figure. Net content is a separate question from purity.

How is Astramide's glutathione tested?

Testing is performed by Krause Analytical, a DEA-registered, ISO/IEC 17025-certified laboratory in Austin, Texas. Lot 2026/02 was analysed by four methods: identity by mass spectral match, chromatographic purity by HPLC-UV/MS, net content by HPLC-UV/MS, and endotoxin by USP 85, which returned below 0.5 EU/mL. Heavy metals, microbial and pH were not performed on this lot.

How should glutathione be stored for research use?

Lyophilized material is stored at -20C and protected from light. Once reconstituted, storage is 2 to 8C with use within 14 to 30 days. Glutathione oxidises readily in solution, so freshly prepared stocks are preferred for redox work. Storage conditions printed on the vial label take precedence.

What is the difference between research-grade and pharmaceutical-grade glutathione?

They are distinct classifications. Research-grade material is supplied for laboratory research use only and is characterised by the analytical panel published on this page. Pharmaceutical-grade is a separate regulatory classification governing material intended for human use. Astramide supplies research-grade material and makes no pharmaceutical-grade claim.

Why is glutathione not a conventional peptide?

The glutamate residue is joined to cysteine through its side-chain gamma-carboxyl group rather than the alpha-carboxyl used in standard peptide bonds. This isopeptide linkage is why glutathione resists most conventional peptidases, and it is the structural reason the molecule persists intracellularly at millimolar concentrations.

Research use only

This product is intended strictly for in-vitro laboratory research conducted by qualified professionals. It is not intended for human or animal consumption, clinical use, or therapeutic application. The statements on this page have not been reviewed by the FDA. These research peptides are not intended to diagnose, treat, cure, or prevent any disease. Research Use Only.

COA library Every lot we have tested Search by batch number. Past lots stay published. How we test The analytical panel What each method measures and the criterion each lot must meet. Open Lab Send us your peptides Any vendor. Same lab. Your own Certificate of Analysis.
Ships from Austin, TexasUPS Ground, about 3 business days
United States onlyFree shipping at $150 and over
Tracked on every orderTracking number emailed when it ships
Replacement or store creditOn approved claims. See refund policy.

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