| Pcs | Single Vial, Pack of 10 |
|---|---|
| Strength | 10 mg |
KPV – Pro
Pro Series
KPV (Lys-Pro-Val), the C-terminal tripeptide of alpha-MSH (11-13)
CAS 67727-97-3C₁₆H₃₀N₄O₄Approximately 342.44 g/mol3 amino acidsLinear peptideLyophilized powder
Price range: $44.99 through $400.00
Why the Pro Series costs more
- Synthesized in the USA. Domestic ground and air only, no ocean freight.
- Released only above 99% HPLC purity.
- Its own lot and its own published certificate.
Ships from Austin, TexasUnited States only
Tested by an outside labNever in-house
Every lot publishedIncluding rejected lots
Same-day dispatchOn orders before 2pm ET
BATCH
VERIFICATION
VERIFICATION
LOT NUMBER
NHS-KPV10-20260812-01
10 mg vial
IDENTITY
Match (C16H30N4O4, 342.43 g/mol)
CHROMATOGRAPHIC PURITY
99%
NET CONTENT
10.0007 mg (100.0% of 10 mg label claim)
Quick reference
How to read this report
Same six keys on every Astramide product page. Only the values change.
1Lot numberMatch it to the number printed on your vial. If they differ, this report is not for your vial.
2IdentityMass spectrometry confirms the molecule is the one on the label. It conforms or it does not. There is no partial result.
3Chromatographic purityThe share of the material that is the target peptide. A purity figure quoted without a method is not a purity figure.
4Net contentHow much peptide is in the vial, as measured by the laboratory. A different question from purity.
5EndotoxinMeasured against a ceiling, not a floor. Sensitivity differs by laboratory, so results are not compared across labs.
6Laboratory, method, dateWho ran it, on what instrument, and when. A report with no named laboratory or no date is not a report.
Molecular profile
KPV - Pro, in structural terms.
- Sequence
- Lys-Pro-Val (KPV)
- Molecular formula
- C₁₆H₃₀N₄O₄
- Molecular weight
- Approximately 342.44 g/mol
- CAS number
- 67727-97-3
- Peptide length
- 3 amino acids
- Structure type
- Linear peptide
- Parent sequence
- alpha-MSH (11-13)
- Primary molecular target
- Peptide transporter 1 (PepT1, SLC15A1), through which KPV uptake has been demonstrated in intestinal epithelial and immune cell lines. No single high-affinity receptor has been established for KPV.
- Physical form
- Lyophilized powder
- PubChem CID
- 125672
KPV is a linear tripeptide of L-lysine, L-proline and L-valine. It corresponds to residues 11 to 13 at the C-terminus of alpha-melanocyte-stimulating hormone (alpha-MSH), a 13-amino-acid peptide derived from proopiomelanocortin. KPV is supplied as the free acid (C16H30N4O4), while the parent alpha-MSH sequence ends in a C-terminal amide.
Research profile
Where KPV - Pro appears in the literature.
Immunology; Cell Biology; Gastrointestinal Biology; Peptide Transport; Melanocortin Biology
Research applications
- Published studies have used KPV in:
- PepT1-mediated peptide uptake studies
- NF-κB pathway activation studies
- MAP kinase signaling studies
- Pro-inflammatory cytokine expression studies
- Melanocortin-derived peptide structure-function research
Experimental systems
- Caco2-BBE human intestinal epithelial cells
- HT29-Cl.19A intestinal epithelial cells
- Jurkat human T cells
- Mouse models of DSS-induced and T-cell transfer intestinal inflammation
- Mice expressing a nonfunctional melanocortin-1 receptor (MC1Re/e)
Specific assays
- PepT1 uptake and competition assays
- NF-κB luciferase reporter assays
- Western blot for MAP kinase phosphorylation
- Real-time RT-PCR
- ELISA
- Myeloperoxidase (MPO) activity assays
Measured endpoints
- PepT1-mediated KPV uptake
- NF-κB activation and IκB-α degradation
- ERK1/2, JNK and p38 MAPK phosphorylation
- Pro-inflammatory cytokine mRNA and protein levels
- Colonic MPO activity and histology in mouse models
Mechanism and research context
What has been studied, and in what systems.
KPV is the C-terminal Lys-Pro-Val tripeptide of alpha-MSH. Reviews of alpha-MSH biology have described KPV as a fragment that has been studied separately from the full hormone because it lacks the parent peptide's pigmentary activity (Brzoska et al., 2008).
In intestinal epithelial and immune cell lines, KPV has been shown to enter cells through the PepT1 di- and tripeptide transporter. Studies have then examined changes in NF-κB and MAP kinase activation and in pro-inflammatory cytokine expression (Dalmasso et al., 2008).
In mouse models, KPV has been examined in two forms of experimentally induced intestinal inflammation. Effects were also observed in mice lacking functional MC1R signaling, which suggests that its activity in these models is not explained by classical melanocortin receptor agonism alone (Kannengiesser et al., 2008).
These are published research systems. They do not describe approved clinical applications, and they do not establish efficacy or safety in humans.
Cited literature
Dalmasso G et al., 2008. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. PMID 18061177. https://pubmed.ncbi.nlm.nih.gov/18061177/
Kannengiesser K et al., 2008. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis. PMID 18092346. https://pubmed.ncbi.nlm.nih.gov/18092346/
Brzoska T et al., 2008. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev. PMID 18612139. https://pubmed.ncbi.nlm.nih.gov/18612139/
Evidence level
The published evidence for KPV consists of cell-line, biochemical and mouse-model studies. Its PepT1 transport has been characterised in vitro. Statements on this page describe experimental systems, not outcomes in humans.
Handling and storage
As supplied
Lyophilized powder in a sealed vial. Held in laboratory-rated freezers from arrival to shipment.
Storage
Store per the conditions printed on the vial label. Avoid heat, moisture and repeated temperature cycling.
Handling
For qualified professionals in controlled laboratory environments, following validated laboratory procedures.
Frequently asked questions
About this compound and its batch data.
What is KPV?
KPV is a linear tripeptide of lysine, proline and valine (Lys-Pro-Val), corresponding to residues 11 to 13 at the C-terminus of alpha-melanocyte-stimulating hormone. Its molecular formula is C16H30N4O4, its molecular weight is about 342.44 g/mol and its CAS number is 67727-97-3. KPV Pro is supplied as a lyophilized powder in a 10 mg vial. Sold for research use only.
What has KPV been examined for in published research?
Published studies have examined KPV uptake through the PepT1 peptide transporter in intestinal epithelial and immune cell lines, and its effects on NF-κB and MAP kinase signaling (Dalmasso et al., 2008, PMID 18061177). Mouse-model studies have examined KPV in experimentally induced intestinal inflammation (Kannengiesser et al., 2008, PMID 18092346). This work was pre-clinical. Astramide makes no claim about outcomes in humans.
What purity does the current KPV Pro lot reach?
Lot NHS-KPV10-20260812-01 returned 99% chromatographic purity by HPLC at 274 nm, reported by pH Solutions Lab on 29 September 2026 under certificate 260923-899-NHS-18. Identity was confirmed as a match to KPV. The lot meets the Pro Series release criterion of at or above 99% HPLC purity. The full certificate is published on this page.
How much KPV is in the vial?
The label claim is 10 mg per vial. For lot NHS-KPV10-20260812-01, the laboratory measured 10.0007 mg of KPV, reported as 100.0% recovery against the 10 mg label claim. Astramide publishes the measured figure exactly as the laboratory reports it. Net content and chromatographic purity are separate measurements and answer different questions.
How should KPV be stored for research use?
Lyophilized KPV is stored at -20°C and protected from light. Once reconstituted, the solution is held at 2 to 8°C and used within 14 to 30 days. Repeated temperature cycling and exposure to moisture should be avoided, because both can affect peptide stability and the comparability of experimental results.
Is KPV Pro the same as the KLOW blend?
No. KLOW is a separate product that combines KPV with BPC-157, GHK-Cu and TB-500 in one vial. KPV Pro contains KPV alone. Each product carries its own lot number and its own Certificate of Analysis. A certificate for one product never applies to another, and a blend is tested as a blend.
How is Astramide's KPV Pro tested?
Lot NHS-KPV10-20260812-01 was tested by pH Solutions Lab, an independent ISO/IEC 17025:2017 accredited laboratory (A2LA R243, PJLA Testing #84351). The certificate reports identity, chromatographic purity at 274 nm, net content, water content, pH, water activity, a 10-organism microbial panel, heavy metals, residual solvents, sterility and mycotoxins. Results apply only to this lot.
What is the difference between KPV and KPV Pro?
KPV Pro is part of the Astramide Pro Series. It is American-made, synthesized in the USA, and moves by domestic ground and air only, with no ocean freight. It is released under its own lot, and only when HPLC purity measures at or above 99%. The full certificate for each lot is published on this page. The standard KPV is released under separate lots with separate certificates.
Research use only
This product is intended strictly for in-vitro laboratory research conducted by qualified professionals. It is not intended for human or animal consumption, clinical use, or therapeutic application. The statements on this page have not been reviewed by the FDA. These research peptides are not intended to diagnose, treat, cure, or prevent any disease. Research Use Only.
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What each method measures and the criterion each lot must meet.
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Replacement or store creditOn approved claims. See refund policy.
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